This research examines whether young people’s literacy on the safe sex issue and their intention to share health-related information would be affected by medium type (websites vs. social networking sites) and message type (fact-based vs. feeling-based contents). A factorial experiment was conducted where respondents were randomly assigned to read one of the four versions of safe sex-related stories that contained the same information but were presented differently. Results showed that website-based contents, as compared with SNS-based contents, facilitated respondents’ safe sex literacy and information sharing intentions. The interaction effect suggested that feeling-based contents yielded a stronger effect on information sharing intentions on the website than the effect found on social networking sites.